Hosted on MSN1mon
A high-resolution 'map' reveals the structural and functional complexity of endogenous NMDA receptors in the brain
has dissected the assembly and architecture of endogenous N-methyl-ᴅ-aspartate receptors (eNMDARs) in the adult mammalian cerebral cortex and hippocampus. Learning and memory are fundamental ...
Hosted on MSN18d
FDA grants breakthrough status to Grin Therapeutics’ radiprodil
The US Food and Drug Administration (FDA) has granted breakthrough therapy designation to Grin Therapeutics’ radiprodil for treating seizures associated with glutamate receptor, ionotropic, N-methyl D ...
Physician's Weekly6d
SLC25A13 as a Prognostic Biomarker and Therapeutic Target in Cancer
The following is a summary of "Unveiling the oncogenic role of SLC25A13: a multi-omics pan-cancer analysis reveals its impact ...
Techno-Science.net12d
Acide aspartique - Définition
L’acide aspartique (dont l'anion s'appelle aspartate) est l'un des 20 acides-α-aminés constituant les protéines. Il s'agit de l'acide carboxylique proche de l'asparagine. C'est un acide dicarboxylique ...
Neurology Advisor6d
Radiprodil Gets Breakthrough Designation for Seizures Associated With Rare Gene Disorder
The FDA has granted Breakthrough Therapy designation to radiprodil for the treatment of seizures associated with GRIN-related neurodevelopmental disorder with GoF mutations.
The Pharma Letter18d
All smiles at GRIN over radiprodil prospects
Neurodevelopmental disorders company GRIN Therapeutics, an affiliate of the Blackstone Life Sciences portfolio company Neurvati Neurosciences, has announced a major milestone.
BioWorld10d
GluN2B signaling regulates dendritic spine plasticity and reverses FXS phenotypes
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and a leading monogenic cause of autism, yet effective treatments remain elusive. Previous work showed that ...