In the presence of oxygen, active hypoxia-inducible factor (HIF) hydroxylases (that is, prolyl hydroxylase domains, PHDs, and factor inhibiting HIF, FIH) downregulate and inactivate HIF1α subunits.
Transcriptional Regulation Using Posttranslational Modifications and Stability There are several hundred genes regulated by hypoxia, and much of that regulation occurs through HIF (Figure 3).
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