Antifungal compounds ... relationship between the chemical structure of a compound and its biological activity, which helps in designing more effective drugs. EC 50: The concentration of a drug ...

Antifungal drugs target molecules in the fungal cell wall, a flexible but rigid outer layer that provides the cell protection. By rupturing the protective structure, the drugs kill the fungal cell ...

Therapeutic drug monitoring (TDM) is a crucial aspect of managing invasive fungal infections, particularly when using antifungal medications like voriconazole. This approach helps ensure that drug ...

Fungi are particularly challenging to treat because their structure is more similar ... Currently, there are only four ...

"The class of drugs called azoles are able to kill off fungal infections by blocking the actions of one of its P450s that is essential for maintaining the cell structure," said Professor Munro. "We ...

DURHAM, N.C. -- For the roughly 150,000 patients with AIDS who come down with a life-threatening infection called fungal meningitis each year, there aren’t many options. In many parts of the world ...