Table 1 Selected companies and their antibacterial and antifungal programs. Full size table In addition, one of the key issues that characterize the current state of antibiotic drug discovery is ...

Much effort is being expended to not only develop new drugs faster than resistance develops, but also understand the basics of resistance itself. For example, antifungal agents are often ...

Antifungal drugs target molecules in the fungal cell wall, a flexible but rigid outer layer that provides the cell protection. By rupturing the protective structure, the drugs kill the fungal cell ...

"The class of drugs called azoles are able to kill off fungal infections by blocking the actions of one of its P450s that is essential for maintaining the cell structure," said Professor Munro. "We ...

DURHAM, N.C. -- For the roughly 150,000 patients with AIDS who come down with a life-threatening infection called fungal meningitis each year, there aren’t many options. In many parts of the world ...