Figure 1: Structure and antifungal activity of amphotericin B and a rationally designed synthetic probe. Given the fact that no conclusive evidence had been provided for the current amphotericin B ...

Mandimycin, which targets a different essential fungi cell resource than other antifungal drugs, should harm other cell types as collateral — but doesn’t.

This property has been less studied in the case of antifungal drugs compared with antibacterials, and most studies concern amphotericin B and its various formulations. [89] Amphotericin B alters ...

However, resistance is widespread and conventional antifungal drug discovery strategies ... such as the clinically used agent ...

Olorofim (formerly F901318) is the first in a new class of orotomide antifungal agents intended ... to Astellas' AmBisome (liposomal amphotericin B) in invasive aspergillosis, which should ...

The pharmacology, bioavailability and pharmacokinetics, clinical efficacy, and adverse effects of caspofungin acetate are reviewed. Caspofungin acetate is an echinocandin with fungicidal activity ...