Intravenous alteplase (recombinant tissue plasminogen activator) is restricted for use within 3 h from stroke onset by marketing authorizations. Some patients are treated beyond this approved time ...

Three 100-mg vials of alteplase injection a were reconstituted with sterile water b to yield solutions of 0.5, 1, and 2 mg/mL. A transfer adapter c was used to draw 1-mL samples into 5- mL plastic ...

The activity and sterility of reconstituted alteplase solution and the effectiveness of an alteplase dose-escalation protocol for the clearance of midlinecatheter and central-venous-access device ...