Potassium and renal function must be routinely assessed to minimize the risk of life-threatening hyperkalemia. This review discusses the role of aldosterone antagonists in the treatment of heart ...

The finding that angiotensin II and aldosterone are proinflammatory ... A reasonable definition of hyperkalemia is a serum potassium concentration of ≥5.5 mmol/l. When using inhibitors of ...

New York, NY) is an aldosterone blocker that works by binding at the mineralocorticoid receptor. It has some similarities to the potassium-sparing diuretic spironolactone, but rarely causes ...

This process is influenced by hormones such as aldosterone, which increases potassium excretion, and is also affected by the body’s acid-base balance. Finally, any excess potassium that is not ...

The key will be not only cost but the adverse event profile. With aldosterone synthase inhibitors, you worry about potassium levels and hyperkalemia. That has been a limitation of these types of ...

Aldosterone antagonists (spironolactone, eplerenone) also known as “potassium sparing diuretics” block the action of aldosterone inhibiting the reuptake of sodium and water. Normally ...

Elevated aldosterone stimulates sodium reabsorption in the cortical collecting duct as a backup mechanism of maintaining homeostasis. This mechanism results in increased potassium and hydrogen ion ...

and for those who take common life-saving medications for heart failure (HF), such as renin-angiotensin-aldosterone system (RAAS) inhibitors, which can increase potassium in the blood. To help ...

Nursing mothers. Avoid concomitant potassium-sparing diuretics. Monitor for hyperkalemia with drugs that inhibit the renin-angiotensin-aldosterone sytem (eg, ACE inhibitors, ARBs, spironolactone ...