Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

If they have moderate to severe heart failure with pulmonary ... diuretic resistance through a different mechanism of action. In recent years, aldosterone antagonists have been found to improve ...

Aldosterone antagonists (spironolactone ... Spironolactone is indicated (class IIa, level of evidence B) in systolic heart failure with recent or current New York Heart Association functional ...

Chronic HF results in the activation of multiple compensatory mechanisms ... The aldosterone antagonist eplerenone was evaluated in the Epleronone Post-Acute Myocardial Infarction Heart Failure ...

It suppresses the renin-angiotensin-aldosterone system. The mechanism of the antihypertensive ... Severe CHF. Ischemic heart disease. Cerebrovascular disease. Arrhythmias. Salt/volume depletion.

Baxdrostat is a drug that reduces aldosterone levels in the body to treat high blood pressure and other conditions. It's an ...