Sodium reabsorption is mainly controlled by aldosterone, a steroid hormone synthesized in the zona glomerulosa of the adrenal gland, secondary to renin stimulation via angiotensin II and to ...

That is the conclusion of the Advance-HTN study reported at the American College of Cardiology (ACC) meeting, which found ...

In turn, patients having been successfully treated with diuretics can occasionally see BP control lapse because of the tendency for diuretics to activate the renin-angiotensin-aldosterone system ...

adding a thiazide diuretic may help overcome diuretic resistance through a different mechanism of action. In recent years, aldosterone antagonists have been found to improve outcomes in patients ...

Initial studies in cynomolgus monkeys demonstrated its ability to decrease aldosterone production, prompting further investigation in humans. The mechanism of action of baxdrostat involves ...

Lisinopril inhibits angiotensin-converting enzyme. It suppresses the renin-angiotensin-aldosterone system. The mechanism of the antihypertensive effect of thiazides is unknown. Fetal toxicity may ...