Lorundrostat, an experimental drug, may help lower blood pressure in people with uncontrolled hypertension, researchers ...

That is the conclusion of the Advance-HTN study reported at the American College of Cardiology (ACC) meeting, which found ...

Among patients with uncontrolled hypertension, the investigational drug lorundrostat brought a significant reduction in blood pressure at 12 weeks compared with placebo, according to a study presented ...

The investigational aldosterone synthase inhibitor lorundrostat effectively lowered 24-hour BP for adults with well-treated, uncontrolled and “true” treatment-resistant hypertension, according to data ...

Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

Drugs that interfere with the renin–angiotensin system can provide renoprotection in patients with diabetic nephropathy, possibly by exerting an antiproteinuric effect. Aldosterone might have a ...

Lisinopril inhibits angiotensin-converting enzyme. It suppresses the renin-angiotensin-aldosterone system. The mechanism of the antihypertensive effect of thiazides is unknown. Fetal toxicity may ...

The aldosterone-renin ratio (ARR) has gained popularity as a screening test for primary hyperaldosteronism, a probably underdiagnosed cause of hypertension. However, studies have yielded varying ...