Spironolactone is a nonselective aldosterone antagonist, and eplerenone is selective to the aldosterone receptor. Although numerous clinical trials have evaluated the efficacy of each drug ...

Significant hyperkalemia did contribute to sudden cardiac death. Note that unfractionated heparin also has aldosterone antagonist effects.

Other recent outcome studies document that resistant hypertension is not rare. In the Controlled ONset Verapamil INvestigation of Cardiovascular End Points trial (CONVINCE), [2] more than 16,600 ...

The finding that angiotensin II and aldosterone are proinflammatory ... Modest doses of a mineralocorticoid-receptor antagonist (for example, 25 mg per day of spironolactone) have been shown ...

"Excess levels of aldosterone are associated with hypertension ... a dual endothelin receptor antagonist (ERA) submitted for approval in the US last month that has been tipped as a potential ...