（四）TMEM45A 通过激活 AKT/mTOR 信号通路促进乳腺癌帕博西尼耐药和糖酵解 GSEA 分析发现，TMEM45A 高表达与 mTORC1 信号通路上调相关。Western blotting 显示，耐药细胞中 AKT/mTOR 信号通路激活，敲低 TMEM45A 降低 p-AKT 和 p-mTOR 表达，恢复帕博西尼对该通路的抑制 ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...