Whatever the mechanisms, it seems that active demethylation can play a role in a neuron’s return to basal gene expression after a learning event 4. Figure 1 | Proposed mechanism of DNA methylation and ...

Further experiments, however, unearthed an unexpectedly complex process, entailing both passive and active mechanisms of DNA demethylation by the ten-eleven translocation (TET) and AID/APOBEC families ...

Biochemically, TET proteins (TET1/2/3) can convert 5mC to 5hmC/5fC/5caC through alpha-ketoglutarate and iron-dependent oxidative reaction, initiating the active or passive DNA demethylation. Given ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...