Genome-wide transcriptomics analysis of IFNγ-producing or IL-17A-producing γδ T cell subpopulations reveals marked differences in their mode of activation and functional potential in the periphery.

Explore how T cell engagers could transform cancer and autoimmune treatments through promising trials and key collaborations.

This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

Joint injury induces rapid and sustained diversification of resident and infiltrating synovial macrophage phenotypes, underpinning osteoarthritis-associated synovitis.

More information: Hongxing Shen et al, HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells, Nature Communications (2024). DOI: 10.1038/s41467 ...

Scientists engineered T cells to protect instead of kill, potentially enabling targeted treatments for autoimmune disease and ...

A better understanding of inflammation and lung immunity over the past two decades has led to new, innovative treatments for ...