Then, the team found that these fat-infiltrating immune cells differ from typical Th2 cells, as they were releasing the powerful cytokine TGFβ as well as Amphiregulin, a molecule that stimulates wound ...

These prodrugs are activated into immune stimulants only in the tumor microenvironment, where they trigger the immune system to ‘predate’ on cancer cells (Fig. 1). This has the potential to ...

In conclusion, Tim-3 was characterized as a novel immune checkpoint molecule with pathophysiological significance in respiratory oncology. Its stage-dependent expression dynamics and multimodal ...