Previous efforts to circumvent the problem of the size limitation imposed by the AAV vector have focused mainly on altering the candidate genes into ‘mini-expression cassettes’ suitable for ...

Many viral vectors have shown promise as gene ... Identification of the AAV receptor and vector-specific reagents has led to the development of purification protocols for rAAV vectors by affinity ...

How to design and launch a successful Clinical Trial Manufacturing.

The Viral Vector & Plasmid DNA Manufacturing Market Size accounted for USD 5.4 Billion in 2023 and is estimated to achieve a ...

Siren said proceeds will go toward investigational new drug (IND)-enabling animal studies and clinical-grade production of ...

Touching Base is the dynamic podcast series from the editors of GEN. Each episode features a rotating case of senior editors—including John Sterling, Kevin Davies, Julianna LeMieux, Alex ...

The VDL is currently restructuring and not providing services at this time. For all request of viral vectors, please visit the Gene Vector Core Website or send an email to [email protected]. Since ...

Concomitantly, the regulatory environment has expanded in parallel to the use of AAV. The ongoing revision of the ICH Q5A guidance—relative to the viral safety of biotechnology products derived from ...

Efficient viral vector production is essential for the cost-effective manufacture of cell and gene therapies. Many of the current production workflows are reliant on basal media in batch-mode, which ...

To ensure they have the materials required for each testing phase, researchers can also rely on off-the-shelf plasmid and viral vector solutions, such as those offered by Charles River as a part of ...