It is a beautiful piece of work. It provides a serious piece of heft to the hypothesis that specialized ribosomes not only exist but have important functional consequences in cellular processes.

Researchers developed a technique to gain a deeper understanding of ribosome function and their cooperative behaviors.

But just how does translation work? In other words ... most of which are associated with the cellular structure known as the ribosome. In order to understand these mechanisms, however, it's ...

METHODS: In biochemist David Giedroc’s lab at Texas A&M University, Cornish studied how ribosomes translate mRNA into proteins, focusing his graduate work on frameshifting, ...

My work benefited immensely from interactions with colleagues like Ada Yonath, who pioneered ribosome crystallography, and Thomas Steitz, who elucidated the large subunit’s structure.

"Ribosomes are very large macromolecular machines that very rapidly and precisely decode mRNA into protein. For a long time, they've been viewed as kind of 'dumb code-reading machines' that don't ...

"Now, if the mitochondrial ribosome does not work, our body cannot produce enough energy coins anymore and this leads to diseases such as neurodegenerative disorders and heart conditions.

We find that these inhibitors slow elongating ribosomes, thereby inducing a queue of pre-initiation complexes that can become positioned over and initiate from an otherwise poorly recognized start ...

These results demonstrated that the ribosome is a ribozyme ... are attached to the membranes. The work of his group on giant multifunctional enzymes involved in fatty acid synthesis offer first ...