Figure 3: The subunit interface between 30S and 50S particles is rich in RNA ... ribosomes are quite homologous, some of the ribosomal proteins bear homology but others do not.

Macrolides bind reversibly to 23S ribosomal RNA (rRNA) of the 50S subunit of bacterial ribosome inhibiting RNA-dependent protein synthesis. Clindamycin (a lincosamide) at subgrowth inhibitory ...