Macrolides bind reversibly to 23S ribosomal RNA (rRNA) of the 50S subunit of bacterial ribosome inhibiting RNA-dependent protein synthesis. Clindamycin (a lincosamide) at subgrowth inhibitory ...
Large Subunit rRNAs: The large subunit in prokaryotes contains the 23S and 5S rRNAs, while in eukaryotes, it contains the 28S, 5.8S, and 5S rRNAs. These rRNAs play a role in peptide bond formation and ...
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