Paramount's Novocaine made $1.75 million in previews and the R-rated action comedy might lead the box office this weekend with anywhere from $8M-$12M,

After starring in last month’s AI thriller “Companion,” Jack Quaid is back at the box office this weekend with “Novocaine,” an action comedy where he plays a man who can’t feel pain. The R-rated film from Paramount has made $1.

Quaid's leading role in Novocaine feels like a natural continuation of these genre-bent everymen. He plays Nathan Caine, a mild-mannered assistant bank manager who has congenital insensitivity to pain with anhidrosis (CIPA), a genetic disorder that impacts his nervous system to the point that he can't feel pain or temperature.